This cytokine hyper-expression, IL-1β, IL-6, IL-15, and TNF-α, at the cardiac level, detected through immunohistochemical investigation and documented on SARS-CoV-2-positive subjects, may be of interest in determining whether there was organ involvement during the infection, correlating cytokine hyper-expression with cardiac distress [26,44]. The gene discussed is IL6; the disease is infection.