Among the enzymes of the nuclear PI cycle, nuclear PI-PLCβ1 plays a fundamental role in the regulation of hematopoietic differentiation, that seems to be related to the recruitment of Myeloid zinc finger-1 (MZF-1) [28], and suggests that this enzyme has a significant impact on the initiation and progression from MDS to AML by affecting both genetic and epigenetic processes [54,55,56]. This evidence concerns the gene MZF1 and myelodysplastic syndrome.