Indeed, after silencing of PLCB1, increased activation of the Stat3 pathway, a well-established oncogenic transcription factor known to play a pivotal role in tumor resistance and aggressive cancer progression in glioblastoma [86] was also observed, thereby strengthening the hypothesis that downregulation of PI-PLCβ1 in glioblastoma promotes a more aggressive phenotype. Here, STAT3 is linked to glioblastoma.