PLCB1 and myelodysplastic syndrome: In contrast, the PLCB4 gene, encoding another signaling molecule and positioned on 20p12.3 within 1Mb of PLCB1, remained unaffected, even in MDS patients exhibiting the deletion of the PLCB1 gene, suggesting a distinct and interstitial deletion pattern for PLCB1 [57,58].