CBLN1 and Alzheimer disease: Similarly, lower levels of Cer d18:1/16:1, Cer d18:1/20:1 and Cer d18:1/24:1 were observed between NEVs compared to multi-origin EVs of AD samples (p = 0.012, p = 0.046, p = 0.074, Table S3), as well as for Cer d18:1/16:0 levels in neuronal and astrocytic EVs compared to multi-origin EVs of control samples (p = 0.010 and p = 0.007, respectively).