Consistent with their subcellular localization, M8/3-nCT, M8/3-nTM, and M8/3-cCT proteins did not inhibit infection by both VSV-G and HIV-1 Env pseudoviruses (Figure 2D,E), whereas M8/3-EC and M8/3-cTM retained their antiviral activity. The gene discussed is ERVW-1; the disease is infection.