Compared to cognitively normal subjects, immunoblotting of the medial temporal cortex of patients with Alzheimer’s disease revealed increases in the expression of the cystine/glutamate transporter, ceruloplasmin, ferritin light chain, and ferritin heavy chain, and trends for decreases of ferroportin and DMT1, but no increase in the amount of elemental iron [81]. This evidence concerns the gene CP and early-onset autosomal dominant Alzheimer disease.