Moreover, the transformed fibroblasts showed signs of a primary tumor: the expression of epithelial markers typical of colorectal adenocarcinoma (CK7, positive for CEA, CK20, CDX-2, and AE1/AE3), markers reflecting early differentiation into pancreatic cancer (positive for cytokeratin CK19 and AE1/AE3, CK7 focal positive patches), and ovarian cancer markers positive for WT-1 and EMA. The gene discussed is KRT7; the disease is familial pancreatic carcinoma.