NIPA1 and amyotrophic lateral sclerosis: Despite these limitations, on the basis that the replication of genetic associations in populations can provide support for the disease causation scenario and, if not replicated, can also raise new questions about undelight pathogenetic processes, our present study provides valuable insights on the frequency of REs in NIPA1, NOP56, and NOTCH2NLC in a cohort of South Italian ALS cases and highlights the need for larger and more comprehensive studies to validate and extend our findings.