In another study comparing HIV+ patients with and without CAD (HIV+CAD+ and HIV+CAD-) and demographically matched seronegative controls with and without CAD (HIV-CAD+ and HIV-CAD-), coronary endothelial function was significantly impaired in the HIV+CAD- group, similar to coronary endothelial function in seronegative subjects with established CAD (HIV-CAD+), and associated with high interleukin (IL)-6 levels [38]. This evidence concerns the gene IL6 and coronary artery disorder.