TGM2 and neuroblastoma: Furthermore, starting from the observation that RA-dependent induction of TG2 did not produce an increase in apoptotic rate in human neuroblastoma SH-SY5Y cells [174], Tucholski and Johnson demonstrated that the pro-apoptotic role of TG2 was dependent on the type of stressors and on how the transamidation activity of the enzyme is affected [175].