LINC01191 and obesity due to melanocortin 4 receptor deficiency: Specifically, two particular cases have been analyzed: one with heterozygous vinculin ablation (VIN +/−), in which normal cardiac development has been demonstrated—unless stress events such as hypertension, obesity, and diabetes occur—and another case with homozygous ablation (VIN −/−), which is associated with a lethal condition [99].