DM is a chronic hyperglycemia condition caused by impairment in insulin secretion, response to insulin, or both alterations [4,5], and is diagnosed by randomly measured glycemia ≥ 200 mg/dL, fasting glycemia ≥ 126 mg/dL, glycemic levels ≥ 200 mg/dL after a 2 h OGTT, and HbA1c ≥ 6.5% [6]. Here, INS is linked to diabetes mellitus.