Overall and disease-free CRC survival increase Reduced liver metastasis [174,175,179]Inhibition of mTOR and PI3K/Akt signaling [176,183]AMPK activation [97,176,183]TGF-β/INHBA signaling suppression [177]CyclinD downregulation [177]Urea cycle suppression [178]Reduced putrescin levels [178]Caspase 3-mediated apoptosis [180]Disruption of tumor-mediated immunosuppression [181,182,183]Chemosensitivity increase [97,184]. This evidence concerns the gene AKT1 and colorectal carcinoma.