In addition, metformin increased SIRT6 expression and decreased inflammatory markers, including SGLT2, leptin, and the leptin/adiponectin ratio, in prediabetic patients with acute myocardial infarction, thus opposing coronary dysfunction, major adverse cardiac events, and prediabetic pericoronary fat accumulation [52,159,160]. Here, LEP is linked to acute myocardial infarction.