To this end, the recognition of signs of the specific moments of prediabetes pathogenesis, such as insulin resistance, low-grade inflammation, altered hormone signaling, oxidative stress, and hyperglycemia, i.e., evaluating fasting glucose levels >100 md/dL or high sensibility CRP values near 2 mg/L, has great potentialities to become a novel bulwark against a CRC pandemic [108]. The gene discussed is CRP; the disease is Hyperglycemia.