The buffalo milk-derived δ-valerobetaine (δVB) exerted a pro-apoptotic effect in SW480 and SW620 CRC cells via PTEN-induced kinase 1 (PINK1)/Parkin pathway activation [130] and induced ROS-mediated apoptosis and SIRT6 upregulation in LoVo cells [131]. This evidence concerns the gene PINK1 and colorectal carcinoma.