Glucose homeostasis enhancement [152,153,155]Inhibition of prediabetes to DM progression [152,153]Increase in GLUT4 expression levels [157]Promotion of GLUT4 membrane translocation [157]Reduction in systemic inflammation and oxidative stress and miR-195 and miR-27 [158]SIRT6 upregulation [159]SGLT2 downregulation [159]Leptin/adiponectin ratio reduction [159]. This evidence concerns the gene SIRT6 and diabetes mellitus.