MLKL and colorectal carcinoma: HCT116 and HT-29 cells treated with the milk-derived miR-27b underwent apoptotic cell death by mitochondrial ROS accumulation [132], while treatment with dietary-derived ergothioneine induced necroptotic death via activation of the SIRT3/Mixed Lineage Kinase Domain Like Pseudokinase (MLKL) pathway in CRC [133].