Clonal hematopoiesis of indeterminate potential (CHIP) is a subset of CH defined by a clonal population of blood cells bearing a point mutation or short/deletion with a variant allele fraction (VAF) ≥ 2% in gene that is recurrently mutated in hematological malignancies like acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative neoplasms, with DNMT3A, TET2, and ASXL1 being the most frequently implicated genes [7,8,9,10]. The gene discussed is TET2; the disease is myelodysplastic syndrome.