AR and posterior cortical atrophy: PTEN/PI-3 kinase, DNA repair, Wnt and cell cycle pathways are altered in 71, 49, 23, 18, >21% of patients, respectively [20,21], and 15 to 20% of PCa patients under hormonal therapies show histological evidence of neuroendocrine prostate cancer (NEPC) cell differentiation or AR-indifference state [22,23,24,25].