Reports from a meta-analysis showed that periodontitis therapy lowered systemic inflammation via reductions in both high-sensitivity CRP (hs-CRP) [0.56 mg/L, 95% confidence interval (CI) (−0.88, −0.25), p < 0.001] and IL-6 [0.48 pg/mL, 95% CI (−0.88, −0.08), p = 0.020] levels [52]. The gene discussed is CRP; the disease is periodontitis.