STAT3 and brain ischemia: This has also been shown in in vitro models with neuronal cells [41]; furthermore, in an in vivo model, it was found that the inhibition of NŦ-κβ by CBD infusion improved cerebral ischemia in rats [42], in addition to increasing the activation of the transcription factor STAT3 and decreasing the activation of STAT1 induced by LPS in BV-2 microglial cells.