The representative DNA methylation profiles of these three receptor genes ESR1, ESR2, and GPER1 in male prostate cancer, female breast invasive carcinoma, uterine corpus endometrial carcinoma, pancreatic adenocarcinoma, hepatocellular carcinoma, and renal papillary cell carcinoma are listed in Figure 3. This evidence concerns the gene ESR2 and Familial prostate cancer.