The analysis revealed that, compared to normal tissues, the levels of ESR1 RNA were significantly decreased in bladder urothelial carcinoma (BLCA), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), cholangiocarcinoma (CHOL), liver hepatocellular carcinoma (LIHC), testicular germ cell tumors (TGCTs), and uterine carcinosarcoma (UCS). This evidence concerns the gene ESR1 and testicular germ cell tumor.