NLRP3 and rheumatoid arthritis: Thus, it was shown that RA patients produced NLRP3 inflammasome components and that patients with active RA had increased intracellular levels of NLRP3 inflammasome components, such as ASC, NLRP3, pro-IL-1β, active caspase-1, as well as increased secretion of IL-1β [176].