FLNA and breast carcinoma: Ji et al. stated that FLNa is overexpressed in breast cancer and colocalizes in the cytoplasm with 14-3-3σ—a multifunctional protein present in most eukaryotic cells and is involved in many cell functions like regulating cytoskeleton, transducing signal, membrane signaling, apoptosis, adhesion, proliferation, and differentiation [47].