The most prevalent genetic pathogenic variants involve sarcomeric proteins, such as TTN (including ACTC and SNTA1) and MYH7 (including SCN5A and NKX2-5), as well as cytoskeletal protein mutations like TAZ (associated with Barth syndrome, including TNN13 and P121L), LDB3 mutations (including TNNT2 and PRDM16), DTNA (including TNNT2 and TPM1), and LMNA (including MYBPC3 and HCN4) (Figure 2) [35,36]. Here, TNNT2 is linked to Barth syndrome.