VHL and nonpapillary renal cell carcinoma: Another significant finding linked to VHL mutation was the nodular tumor enhancement (p = 0.021) of ccRCC and evidence of intratumoral vascularity (p = 0.018) at CT images, that could probably be explained by the fact that a loss of VHL function relates to the upregulation of hypoxia inducible factors and an overexpression of angiogenic factors.