On the contrary, constitutive Nrf2 activation or its overactivation promotes carcinogenesis in plural ways: metabolic reprogramming, cell-cycle regulation [24], healthy mitochondrial maintenance [18,25], induction of angiogenesis [26], suppression of cell apoptosis [27], reduction of tumor-associated chronic inflammation, maintenance of the self-renewal potential of cancer stem cells, and contribution to chemo- and radio-resistance [16]. Here, NFE2L2 is linked to cancer.