In BC, NR4A1 acts as a pro-oncogenic factor regulating ITGB1 and TXNDC5; however, methylene-substituted bis-indole derivative 1,1-bis(3′-indolyl)-1-(p-hydroxyphenyl) methane (DIM-C-pPhOH) acts as an NR4A1 antagonist. The gene discussed is ITGB1; the disease is breast cancer.