TXNDC5 responds to ER stress in RA synovial fibroblast-like cells (RASFs) as its expression is induced by ER stress at both endogenous and secretory levels, whereas, silencing TXNDC5 attenuated the induction of IL6 and CXCL8 from RASFs in response to ER stress [40,167]. Here, TXNDC5 is linked to rheumatoid arthritis.