Piperlongumine and DIM-C-pPhOH are anticancer agents or specifically NR4A1 antagonists that act primarily as inducers of ROS by downregulating the pro-reductant IDH1, TXNDC5, and SESN2 which activate the AMPK and inhibit mTOR activation in CRC [70,71]. The gene discussed is TXNDC5; the disease is colorectal carcinoma.