TXNDC5, accompanied by APOA1, ALB, SERPINA1, HLA-B, and HP, was found to be significantly upregulated in cSCC compared to AK samples, while BD lesions showed moderate to strong cytoplasmic TXNDC5; in contrast, no TXNDC5 was observed in the cytoplasm of normal epidermal cells (Table 3). Here, TXNDC5 is linked to Behcet disease.