A study found that knocking down TXNDC5 along with SRXN1 reduced the time needed for splicing XBP1 and spliced XBP1, resulting in the decreased expression of HSPA5 [91,92], and among the handful of proteins that interact with SRXN1, PRDX6, PDIA6, and TXNDC5 were identified in lung cancer [86,91]. This evidence concerns the gene TXNDC5 and lung carcinoma.