Notably, during simvastatin-induced cell death through c-Jun N-terminal kinase (JNK) activation in DU145 human prostate cancer cells, TXNDC5 exhibited an opposite effect to vimentin, RAB1B, HMGCR, HNRNPK, NDRG1, and IDI1, as it was downregulated despite an increase in its molecular weight, suggesting significant post-translational modification [50]. This evidence concerns the gene TXNDC5 and Familial prostate cancer.