CCL26/eosinophil-attracting chemokine (eotaxin-3), CCL27/CTACK, CCL18/pulmonary and activation-regulated chemokine, and CCL22/macrophage-derived chemokine (MDC) [22] signify increased migration of T-cells, eosinophils, and macrophages to the skin, insinuating how the immune dysregulation is a major driver of the AD. This evidence concerns the gene CCL22 and Alzheimer disease.