TP53 and lung cancer: Hsu et al. showed that baicalein could downregulate the expression of cyclin D2, A, CDK1 and 2, and upregulate the expression of p15, p21, p53, and cyclin E in murine cardiac endothelial cells, which caused endothelial cells to stagnate in the G1 and G2 phases [131], and baicalein was able to induce the apoptosis of lung cancer CH27 cells and caused lung squamous cancer cells to stagnate in the S-phase through the downregulation of the CDK4, the cyclin B1, and D1 expression [132].