A study by Lan et al. (2013) [31] showed that in a group of SCOS patients, the upregulation of SOX9 in conjunction with the downregulation of AR in Sertoli cells may explain the upregulation of AMH expression in these cells We reported here that not only patients with SCOS but also those with severe HypoSp highly expressed AMH in 67% and 100% of patients, respectively, having high FSH levels. The gene discussed is AR; the disease is small cell osteogenic sarcoma.