INS and Hyperglycemia: Similar our results, Sun et al. [3] and He et al. [5] found that MSCs-Exs effectively decreased FBG, increased insulin release, and alleviated hyperglycemia in STZ-treated diabetic rats [28,29] as well as STZ-treated diabetic mice [30], likely via restoring both normal β-islet structure and function, inhibiting β-cell apoptosis and promoting their proliferation, promoting glycolysis/glycogen synthesis, and inhibiting gluconeogenesis.