INS and Hyperglycemia: Regarding nano selenium (NSe), Al-Quraishy et al. [44] reported that the treatment of STZ-diabetic rats with NSe (0.1 mg/kg orally for 28 days) greatly alleviated hyperglycemia, possibly by eliciting insulin-mimetic activity, evidenced by the significant decline in FBG levels coupled with a marked elevation in insulin secretion and liver glycogen content, through enhancing the activity of glucose-6-phosphate dehydrogenase while reversing the abnormal activity of some gluconeogenic and glycolytic liver enzymes.