Jointly considering our new results at DNA methylation levels and the earlier discovery of IFI27 in COVID-19 infections, it may be safe to infer that the CpG site cg16785077 (MX1) played a role in SARS-CoV-2 transmissions and led to influenza-like symptoms through IFI27 (NP/OP). This evidence concerns the gene IFI27 and influenza.