Interestingly, the TFEB level is dysregulated in HD-MSNs; however, it has been demonstrated that reducing the interaction between the regulator of calcineurin (RCAN1) and calcineurin (CaN) promotes the nuclear localization of TFEB and the clearance of HTT inclusion bodies as well as enhances neuronal survival of HD-MSNs [68]. Here, NUP214 is linked to Huntington disease.