SOD1 and amyotrophic lateral sclerosis: While the majority of ALS cases are sporadic, about 10–15% are caused by mutations in several genes including Superoxide dismutase 1 (SOD1), Tar DNA binding protein (TARDBP), Chromosome 9 open frame 72 (C9ORF72), and Fused in Sarcoma (FUS) [23,24].