Gitelman and Bartter Syndromes (GS/BS) are two rare genetic tubulopathies characterized by metabolic alkalosis, hypokalemia (hypomagnesemia in GS), hyperactivation of RAS, and high Ang II and aldosterone level, yet normo/hypotension [9,10] and activation of the RAS counter-regulatory arm with increased ACE2 and Ang 1–7 levels, resulting in antiatherosclerotic, antiproliferative, and antifibrotic effects [5,11]. This evidence concerns the gene AGT and Bartter syndrome.