The analysis revealed that hypertension and the higher levels of neutrophils counts, CRP, CK-MB, NT-proBNP, CREA, and GGT were important adverse factors to aggravate the severity of Omicron BA.1 infection, while the higher lymphocytes level was an independent protective factor for relieving the severity of the Omicron BA.1 infection. Here, NPPB is linked to hypertensive disorder.