Wang and colleagues reported that deletion of sorting nexin 10 (SNX10) or treatment with its inhibitor DC-SX029 restored MV-induced intestinal barrier dysfunction and alleviated colitis in mice by blocking cytosolic MV-LPS release and further downstream signaling.71 The blockade of autophagy using chloroquine and inhibition of miR-574-5p/CARD3 axis ameliorated epithelial barrier dysfunction, autophagy activation, and subsequently, colitis severity mediated by Fn-MVs in vitro and in vivo. Here, RIPK2 is linked to colitis.