A recent worldwide systematic review and meta-analysis, using data collected during 1974–2020, reported an overall case-fatality rate of 11.7% for humans with acute CCHFV infection (defined as presence of live virus, viral antigen, or RNA), a prevalence of 22.5% (n = 35,198), recent infection (defined as presence of IgM) seroprevalence of 11.6% (n = 27,173), and an overall past infection (defined as presence of IgG) seroprevalence of 4.3% (n = 74,900) in humans (11). Here, CD40LG is linked to infection.