In 2006, Ergonul et al. (46) defined severe CCHF as the presence of any of thrombocytopenia (<20,000/mm3), AST >700 U/L or ALT >900 U/L, aPTT >60 seconds, or fibrinogen <110 mg/dL, in addition to the presence of melena, hematemesis, or somnolence. The gene discussed is GPT; the disease is Thrombocytopenia.