Different from other case reports of long OS in EGFR‐mutant NSCLC patients with initially asymptomatic, solitary BM or initially no BM after four‐line therapies including combination with radiotherapy, or off‐label use of osimertinib (double dose),19, 20 the patient in this report had more poor prognostic factors, including EGFR L858R and initially diagnosed symptomatic multiple BM. This evidence concerns the gene EGFR and non-small cell lung carcinoma.