HD is a fatal ND characterized by severe psychiatric symptoms and cognitive impairment (Bates et al., 2015), which is usually inherited in an autosomal dominant manner and is primarily caused by abnormal triple amplification of CAG (cytosine adenine guanine) in the Huntington (HTT) gene on chromosome 4p16.3 (Yang et al., 2020a; Tabrizi et al., 2020). This evidence concerns the gene HTT and Huntington disease.