Tyler et al. achieved successful construction of a mouse model for small cell lung cancer (SCLC) by simultaneously knocking out tumor suppressor genes Trp53 and Rb1 using CRISPR/Cas9 technology (Ng et al., 2020), their study provides an applicable mouse model of humanized SCLC that is suitable for studying the pathogenesis of SCLC. This evidence concerns the gene TP53 and small cell lung carcinoma.