Tyler et al. achieved successful construction of a mouse model for small cell lung cancer (SCLC) by simultaneously knocking out tumor suppressor genes Trp53 and Rb1 using CRISPR/Cas9 technology (Ng et al., 2020), their study provides an applicable mouse model of humanized SCLC that is suitable for studying the pathogenesis of SCLC. The gene discussed is RB1; the disease is small cell lung carcinoma.