The overrepresentation analysis of transcripts having positive correlation with BBLN levels in right heart specimens of TOF patients with cyanosis and showing upregulation in right ventricles of Tg-BBLN mice documented that BBLN triggered major biological pathways involved in heart remodeling (Figs. 2j and 3a and Supplementary Dataset 1). The gene discussed is BBLN; the disease is Cyanosis.