RPL3L and atrial fibrillation: A significant but modest association between RPL3L and AF was also detected (OR = 1.22 (1.11–1.34) for all missense variants; PCauchy = 9.1 × 10−5, FDR QCauchy = 0.005), which is consistent with reported GWAS associations with AF for low frequency RPL3L missense and splice donor variants27,28.