As mentioned earlier, WR might also be a result of changes and imbalances in the gut and adipocyte hormones, which comprise rising ghrelin, neuropeptide Y (NPY), insulin sensitivity, and dropped peptide YY (PYY), cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), serotonin, and leptin and eventually hypoglycemic, and even insulin resistance (17, 36, 49, 50). This evidence concerns the gene LEP and Insulin resistance.