Specifically, genes associated with the mitochondrial electron transport chain (ETC) complex I (including NDUFA13, NDUFA9 and NDUFB8), complex II (SDHAF2 and SDHD), complex III (including UQCR10, UQCR11 and UQCRB), complex IV (including COX16, COX6A1 and COX8A) and ATP synthase (including ATP5F1A, ATP5MF and ATP5PO) had increased expression within LV cardiomyocytes of patients with CAD compared to donor control samples (Fig. 2d). Here, COX8A is linked to coronary artery disorder.