Finally, the snRNA-seq data provided additional evidence that metabolism is similar between LV regions with and without inducible ischemia, including expression of genes encoding the ETC complexes, glucose metabolism (including GLUT1 and GLUT4 transporters) and bioenergetic regulation (including AMP-activated protein kinase and PGC-1α). The gene discussed is PPARGC1A; the disease is ischemia.