A great number of antihypertensive drugs present adverse effects that could interfere in the relationship between patient and prescribed treatment, such as bronchospasm and bradycardia by beta-blockers; dry cough by angiotensin-converting enzyme inhibitors; malleolar edema and headache by calcium channel blockers; sedation, dry mouth, and autoimmune reactions with the agonist of alpha-central action; cramps, fatigue, and sexual dysfunction with diuretics (Malachias, 2016). The gene discussed is ACE; the disease is sexual dysfunction.