Considering that the NMDA receptor family includes seven subunits: GluN1, GluN2A-D, and GluN3A-B, of which GluN2D is only associated with cognitive impairments and motor sensitization, as well as persistent antidepressant effects induced by (R)-ketamine, it is essentially unrelated to the effects of (R, S)-ketamine and (S)-ketamine (Ide et al., 2017; Ide and Ikeda, 2018; Ide et al., 2019). This evidence concerns the gene GRIN2D and Cognitive impairment.