TP53 and cancer: ROS-mediated cancer cell death caused by 50 μM Cym A was proved in comparison with 300 μM H2O2 to upregulate P53 (Figures 7A, B, H, I) and BAX (Figures 7A, E, H, L), deactivate AKT (Figures 7A, C, H, J) and ERK (Figures 7A, D, H, K), and downregulate BCL-2 (Figures 7A, F, H, M) and MCL-1 (Figures 7A, G, H, N).