Zhou et al. (2019), in a murine model of transverse aortic constriction, tested the effects of AVE in combination with intraperitoneal captopril. Coadministration of these compounds completely prevented macrophage infiltration in the aortic adventitia. However, there was an accumulation of cells still present (Zhou et al., 2019). In another study of Ang II-induced hypertension in rats, AVE treatment in combination with alamandine reduced inflammatory stress related to the increase in MCP-1 (Tanrıverdi et al., 2023). This evidence concerns the gene AGT and Hypertension.