In summary, we were the first to evaluate the effectiveness of MX on intestinal adenomas and CRC, further multiomics integration analysis revealed that MX can restore the dysregulated gut microbiota and associated metabolism in CRC mice, in which MX exert the role of anti‐CRC by mostly regulating the Lactobacillus–BA–FXR axis. The gene discussed is NR1H4; the disease is colorectal carcinoma.