SCN1A and Alzheimer disease: Indeed abnormal Nav1.1 activity in PV basket cells have been identified as one of the possible contributory causes to network hyperexcitability in transgenic AD mice.11 While much of the details of cellular and molecular details of these relationships are yet to be identified, the current results clearly emphasize that abnormal gamma PAC is a key manifestations of altered neural syntax closely coupled to epileptogenic processes associated with AD pathophysiology.