found that the levels of exosomal tctex1 domain-containing 2 (TCTEX1D2) were increased in poorly differentiated tumors relative to differentiated tumors, and proposed that TCTEX1D2 may function as a biomarker for the non-invasive prediction of prognosis in CCA (106). The gene discussed is DYNLT2B; the disease is cholangiocarcinoma.