Recently, another similar study reported that the exosomal-associated long non-coding RNA (lncRNA) HCG18 modulates CCA growth and metastasis through the miR-424-5p/SOX9 axis and the PI3K/AKT pathway, with miR-424-5p inhibition reversing the suppression of CCA induced by HCG18 knockdown (80). This evidence concerns the gene SOX9 and cholangiocarcinoma.