Moreover, the AUC value of Cripto-1 for pCCA diagnosis (0.874) was much higher than the AUC values of CA19-9, CEA, and the combined AUC values of CA19-9 and CEA (0.773, 0.596, and 0.773, respectively) (109). Here, CEACAM5 is linked to progressive cerebello-cerebral atrophy.