To assess the effect of PKP2 restoration on desmosomal integrity, we next transduced the PKP2 mutant iPS-cell-derived CMs with either AAV6–PKP2 or an empty AAV6 vector (AAV6-ctr) and performed mRNA and protein analysis at 4 days and 7 days post-infection, respectively (Fig. 1b). This evidence concerns the gene PKP2 and infection.