To characterize the dynamic pattern of the marrow EPC response, we employed a mouse model of systemic E. coli infection and observed that the marrow pool of EPCs with surface markers of LKS VGFR2+ and LKS CD133+VGFR2+ expanded rapidly in the early stage of septic infection (Figures 1, 2). This evidence concerns the gene PROM1 and escherichia coli infection.