Examples include: CD133-CAR macrophages against glioblastoma (184), CD19-CAR macrophages against leukemia cell lines (178), mesothelin-CAR macrophages against ovarian or pancreatic cancer cell lines (178), GD2-CAR macrophages against neuroblastoma (177), GPC3-CAR macrophages against hepatocellular carcinoma (181), anaplastic lymphoma kinase (ALK)-CAR macrophages against neuroblastoma (183), and CEA-CAR macrophages against CEA+ tumor cells (CEA is a cell adhesion protein upregulated in various solid tumors) (174). The gene discussed is ALK; the disease is hepatocellular carcinoma.